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Antiulcer medications: Mechanism of action, pharmacology, and side effects. Famotidine 0.5 mg/kg/dose (Max: 20 mg) (1 - 3mo)DAILY, (≥3mo)BID DAILY-BID Dose: 0.5 mg/kg/day orally daily; Age 3 months to 16 years old. Dosage for H2RAs: Ranitidine (Zantac): 5 to 10 mg/kg/day divided twice daily (max 300 mg/day) Famotidine (Pepcid): 1mg/kg/day divided twice daily (max 80 mg/day) Ages 1 to 21 years: B egin a PPI as follows: Lansoprazole (Prevacid) † o < 30 kg: 15 mg once daily Famotidine EG dosing Usual Adult Dose for Duodenal Ulcer: Initial: Parenteral: 20 mg IV every 12 hours. . Dose: 5 mg PO/NG qd; Alt: start 1 mg/kg/day PO/NG divided qd-bid, then 0.2-3.5 mg/kg/day PO/NG divided qd-bid; Info: for short-term and maintenance tx; consider decr. The studies described in PRECAUTIONS, Pediatric Patients 1-16 years of age suggest the following starting doses in pediatric patients 1-16 years of age: Peptic ulcer - 0.5 mg/kg/day p.o. It is FDA approved for the treatment of gastroesophageal reflux disease (GERD) and is also used off-label for a variety of other gastrointestinal disorders. Available is famotidine oral suspension 40 mg/5 lm. The dosage of famotidine in patients with pathological hypersecretory conditions varies with the individual patient. . . risk of CYP2C19 poor metabolizer); give before meals; may open cap, see PPI Administration Alternatives table. Age 6 months to 11 years old. famotidine - UpToDate. Recommended pediatric dosage by indication (2.2): Peptic Ulcer Disease : 1 year to less than 17 years Starting dosage 0.5 mg/kg once daily; or . Updated: 3 August, 2019. Paediatric population: The efficacy and safety of famotidine in children have not been established. Dosing: Pediatric. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location - one . What is this drug used for? It is used to treat heartburn and sour stomach. Carefully measure the dose using a special measuring device/spoon. Parenteral: -Initial dose: 0.25 mg/kg IV injected over at least 2 minutes OR infused over 15 minutes every 12 hours. Proposed daily dosage in NCT04370262 is 9 times the usual manufacturer-recommended IV adult dosage; the study excludes patients with creatinine clearance (Clcr) ≤50 mL/minute, including dialysis patients . Dose adjustment will be needed for pediatric population with hepatic dysfunction because the drug can accumulate, causing toxicity especially in patients with concomitant renal . Dosage For Pediatric Patients 1-16 Years Of Age See PRECAUTIONS, Pediatric Patients 1-16 years of age. Administration. Go to Pediatric Parenteral Administration Information for famotidine GERD Oral 0.5 - 1 mg/kg/dose PO once to twice daily Maximum: 40 mg/24h Intravenous Less than 1 year Famotidine (Pepcid) is an oral drug used to treat symptoms of acid reflux and heartburn. It is available as both generic and brand drug (commonly known as Pepcid). Common Trade Names: Pepcid, Pepcid AC; Adult Dosing Active duodenal ulcer. Dosage in Renal Impairment after dialysis; no supplement; PD: give 25% usual divided dose q24h; no supplement hepatic dosing [not defined] Patients should also be receiving conservative measures (e.g., thickened feedings). It is used to treat syndromes caused by lots of stomach acid. 1-17 years: 0.25 mg/kg IV q12hr or 0.5 mg/kg PO at bedtime; may increase to 1 mg/kg once daily at bedtime or 0.5 mg/kg twice daily for up to 8 weeks; not to exceed 40 mg/day. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Consider treatment with H2RA or PPI (see Tier 3 for PPI dosages). With parental consent, 107 infants and children (ASA I status, 4 months to 14 years old, NPO for at least 6 h) received either no famotidine (n = 29) or 0.15 mg/kg (n = 27), 0.3 mg/kg (n = 25) or 0.6 mg/kg (n = 26) famotidine at 7.00 a.m. Children Dosage: Not recommended. 10-20 mg every 12 hours, it may take 15-60 min before eating foods that could cause heartburn. Dose: 150 . dose in Asian pts (incr. Note: in Oct. 2005, the FDA approved revisions to the safety labeling for famotidine chewable tablets, Gelcaps®, the original and maximum strength film-coated tablets (Pepcid AC®, made by Merck), and famotidine/calcium carbonate/magnesium hydroxide tablets (Pepcid Complete®, made by Merck) to . The recommended dosage and duration of PEPCID for oral suspension in adults with normal renal function is shown in Table 1. Pediatric Dosage Calculator. Gastroesophageal Reflux Disease (GERD) - 0.5 mg/kg/dose of famotidine oral suspension for the treatment of GERD for up to 8 weeks once daily in patients <3 months of age and 0.5 mg/kg/dose twice daily in patients 3 months to <1 year of age. Renal impairment For famotidine Seizures reported very rarely. Find information on Famotidine (Pepcid) in Davis's Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Gastroesophageal Reflux Disease. The dose of IV famotidine used in the COVID-19 clinical trial (360 mg per day) is substantially higher than the standard dose used for treatment of GI issues. Do not use a trailing zero.) Table 2: Recommended Maximum Dosage of Famotidine Tablets in Adults and Pediatric Patients 40 kg and Greater with Moderate and Severe Renal Impairment Indication Creatinine clearence 30 to 60mL/minute Creatinine clearence less than 30 mL/minute Active duodenal ulcer (DU) 20mg once daily; or 40mg every other day 20mg every other day a Children—Use and dose must be determined by your doctor. Adult: Not defined; Pediatric:Not defined; Contraindications. The use of PEPCID 20 mg and 40 mg tablets is not recommended for use in pediatric patients weighing less than 40 kg because the lowest available strength (20 mg) exceeds the recommended dose for these patients. Children—Use and dose must be determined by your doctor. The use of PEPCID 20 mg and 40 mg tablets is not recommended in pediatric patients weighing less than 40 kg because the lowest available strength (20 mg) exceeds the recommended dose for these patients. PEPCID SUSPENSION prescription and dosage sizes information for physicians and healthcare professionals. Dose: 0.5 mg/kg orally twice daily; Nizatidine (Axid) 15 mg/ml. PEPCID prescription and dosage sizes information for physicians and healthcare professionals. Further sizeable placebo-controlled evaluations of histamine-2 receptor antagonists in infants with gastro-oesophageal reflux disease are warranted. a Using the Sigmoid E max model, serum concentrations of famotidine associated with 50% maximum gastric acid reduction are presented as means ± SD.. The recommended adult intravenous dose is 20mg q 12 h. . If you forget a dose of prescription famotidine, take the missed dose as soon as you remember it. This is because the strengths of these tablets are greater than the recommended dose for these children. Children 12 years or older: 10-20 mg every 12 hours, may take 15-60 min before eating foods that could cause heartburn. Do not use a household spoon because you may not get the correct dose. (65% to 70%) of a famotidine dose is excreted in the urine; 30% to 35% of the dose is metabolized by the liver. For famotidine Present in milk—not known to be harmful but manufacturer advises avoid. It is used to treat or prevent GI (gastrointestinal) ulcers. Creatinine clearance less than 50 mL/min: Give 50% of usual dose, or prolong dosing interval to q36-48hr. In a double-blind, randomized, treatment-withdrawal study, 35 pediatric patients <1 year of age who were diagnosed as having gastroesophageal reflux disease were treated for up to 4 weeks with famotidine oral suspension (0.5 mg/kg/dose or 1 mg/kg/dose). Pediatric Dosing for Lansoprazole (Prevacid®) - Dosing dependent on age & weight Age - Dose per day (mg/kg/dose) < 3 months: 1.5 to 1.75 mg/kg three times per day [this means take the recommended MG and MULTIPLY by baby's weight in KGS. -Maximum dose: 40 mg/day. Use of famotidine in pediatric patients 1-16 years of age is supported by evidence from adequate and well-controlled studies of famoti-dine in adults, and by thefollowing . The use of famotidine and the recommended dosage of famotidine in these pediatric patients is supported by evidence from adequate and well-controlled studies of famotidine in adults and published pharmacokinetic and pharmacodynamic data in pediatric patients [see Dosage and Administration (2.1), Clinical Pharmacology (12.2, 12.3)]. how many mL should the nurse administer per dose? Parenteral famotidine is typically given in a dose of 20 mg every 12 hours. Shake the bottle well for 5 to10 seconds before each dose. Dose: 10 mg IV qd up to 10 days [IV route, 12 mo-17 yo, >55 kg] Dose: 20 mg IV qd up to 10 days *H. pylori infection [15-24 kg] Dose: 20 mg PO/NG bid x10-14 days; Info: part of multi-drug regimen; search H. pylori Tx Regimens for guidelines; give >15min before meals; may open cap, see PPI Administration Alternatives table [25-34 kg] Brand Name: Apo-Famotidine (CAN), Novo-Famotidine (CAN), Pepcid, Pepcid AC, . Since 20 mg or 40 mg tablet strength cannot be used for this dosage regimen, use an alternate famotidine formulation. Famotidine is a competitive inhibitor of histamine H2-receptors. This should not be used in newborns or in pregnant women unless in a single-dose vial. Infants 3 to 11 months Safe pediatric dosages can be calculated from adult doses based on child's weight in kilograms. In adult patients with moderate (creatinine clearance <50 mL/min) or severe (creatinine clearance <10 mL/min) renal insufficiency, the elimination half-life of famotidine is increased. Pharmacology, adverse reactions, warnings and side effects. 10mg (Pepcid AC, generic) 20mg (Pepcid AC) Peptic Ulcer. These data support a starting paediatric dosage for intravenous famotidine of 0.5 mg/kg every 8 to 12 hours. Famotidine is an over-the-counter histamine type 2 receptor antagonist that inhibits gastric secretion. While famotidine may be effective in patients with less severe GERD, proton pump inhibitors (PPIs) offer more rapid symptom relief and better healing. This post on Vital Health extensively discusses Famotidine, its uses, dosage and possible side effects.. Famotidine is a drug made for the treatment of acid reflux and heartburn. Alternatively, some clinicians recommend a continuous IV infusion of 3.2 mg/hour for up to 72 hours following a 10 mg IV bolus dose. 1 TO 16 YEARS: Oral: -Usual dose: 0.5 mg/kg orally once a day at bedtime OR 0.25 mg/kg orally 2 times a day. Table 2: Recommended Maximum Dosage of Famotidine Tablets in Adults and Pediatric Patients 40 kg and Greater with Moderate and Severe Renal Impairment An alternate dosage regimen is 10 mg once daily. NDC 55390-027-01, 20 mL multidose vial, individually boxed. For oral use. Famotidine tablets can be taken with or without food (see section 5.2). Use another famotidine formulation for pediatric patients weighing less than 40 kg. Store famotidine injection at 2° to 8°C (36° to 46°F). In addition, the safety and efficacy of famotidine in the treatment of peptic ulcer disease and esophagitis in paediatric patients is supported by these studies involving over 150 children. Children weighing less than 40 kg—Use and dose be determined by your doctor. Dose: 5-10 mg/kg/day divided every 12 hours; Adult dosing over age 12 years old. Method of administration. (round the answer to the nearest tenth. Patients who took famotidine in this trial experienced a decrease of inflammation within the body and reported earlier alleviation of symptoms. Modifications Doses used for famotidine are adjusted for elderly adults, people who have kidney disease, and for children who weigh less than 40 kilograms ([kg] 88 pounds). renal dosing [see below] CrCl 30-50: give usual divided dose q24h; CrCl 10-29: give 50% usual divided dose q24h; CrCl 10: give 25% usual divided dose q24h HD: give 25% usual divided dose q24h, on dialysis days admin. Maintenance therapy Adults—20 milligrams (mg) once a day. Treat for 6 to 12 weeks. In this prospective, double-blind, controlled trial, 25 patients with urticaria of less than 72 h duration were randomized to receive a single dose of either famotidine 20 mg i.m. The dosage of famotidine in patients with pathological hypersecretory conditions varies with the individual patient. It is used to treat gastroesophageal reflux disease (GERD; acid reflux). Generic Name: famotidine. PEPCID COMPLETE Warnings/Precautions . The S-oxide metabolite is the only 1 identified in humans. Use of famotidine in pediatric patients 1 to 16 years of age is supported by evidence from adequate and well-controlled studies of famotidine in adults, and by the . Pediatric Drug Dosing Guidelines famotidine Famotidine is associated with QT interval prolongation, caution with other drugs or conditions associated with QT interval prolongation. Famotidine elimination half-life is 2 . The recommended dosage in adult patients is 20 mg intravenously q 12 h. Pediatric Patients 1-16 years of age suggest that the starting dose in pediatric patients 1-16 years of age is 0.25 mg/kg intravenously (injected over a period of not less than two minutes or as a 15-minute infusion) q 12 h up to 40 mg/day. Famotidine is being given IV in 120-mg doses three times daily for a maximum of 14 days or until hospital discharge, whichever comes first. Dosage forms: TAB: 10 mg, 20 mg, 40 mg; SUSP: 40 mg per 5 mL; INJ: various duodenal ulcer, active [40 mg PO qhs x4-8wk] Alt: 20 mg PO bid or 20 mg IV q12h; Info: if unable to take PO may use IV short-term only up to 40 mg/day. Histamine-2 receptor antagonists (H2RAs) (eg, cimetidine, famotidine, and nizatidine) inhibit acid secretion by blocking H2 receptors on the parietal cell H2RAs are …. Abacavir (Ziagen) 16mg/kg/day 100mg/tsp 2x/day Acetaminophen (Tylenol) 40-60mg/kg/day 160mg/tsp 6x/day Acetaminophen Infant Drops (Tylenol) 40-60mg/kg/day 80mg/0.8cc 6x/day Amantadine (Rimantadine) 10mg/kg/day 50mg/tsp 2x/day Ampicillin 60-100mg/kg/day 125mg/tsp 250mg/tsp 4x/day . In a double-blind, randomized, treatment-withdrawal study, 35 pediatric patients < 1 year of age who were diagnosed as having gastroesophageal reflux disease were treated for up to 4 weeks with famotidine oral suspension (0.5 mg/kg/dose or 1 mg/kg/dose). -Maximum dose: 40 mg/day. The dosage of famotidine in patients with pathological hypersecretory conditions varies with the individual patient. Storage. Dosage. Use another famotidine formulation for pediatric patients weighing less than 40 kg. The studies described in PRECAUTIONS, Pediatric Patients <1 year of age suggest the following starting doses in pediatric patients<1 year of age: Gastroesophageal Reflux Disease (GERD) - 0.5 mg/kg/dose of famotidine oral suspension for the treatment of GERD for up to 8 weeks once daily in patients <3 months of age and 0.5 mg/kg/dose twice daily . Pepcid is available via injection, suspension or tablet. Dose: 800 mg orally twice daily; Famotidine (Pepcid) 40 mg/5ml oral suspension. pediatric patients weighing less than 40 kg because the lowest available strength (20 mg) exceeds the recommended dose for these patients. GERD: Oral: Suspension: Infants <3 months: 0.5 mg/kg/dose once daily for up to 8 weeks; if not . . Learn about side effects, warnings, dosage, and more. . Adult Dosing . Pediatric Dosage Calculations-- The first section of this topic is shown below --General. Department of Pediatrics, the recommended famotidine dosing regimen at th e Children's Medical Center at the University of Virginia is 0.4 mg/kg given PO or IV every 8 hours. This pilot study will constitute the . Famotidine tablets are not recommended for use in children weighing less than 40 kg (88 lbs.). Refer to adult dosing. Famotidine oral tablet [44392] No dosage adjustment is needed in patients with mild renal impairment (CrCl more than 60 mL/minute). Infants receiving 0.5 mg/kg intravenously were divided into two groups by age, and pharmacokinetic parameters in infants 0-3 months and >3 to 12 months of age were compared. Adults—20 milligrams (mg) once a day. It may be given to your child for other reasons. Usual Pediatric Dose for Gastroesophageal Reflux Disease: Infants 1 to 3 months: Oral: GERD: 0.5 mg/kg . Do not take famotidine if you: are allergic to any component of famotidine products; have a history of allergy to other H2-receptor . Treatment should be given for 4 - 8 weeks, but the duration of treatment may be shortened if endoscopy reveals that the ulcer has healed. <3 months: 0.5 mg/kg PO once daily; may increase to 1 mg/kg once daily for up to . In children, the dosage may also be based on body . Brief Summary: The purpose of this study is to determine whether oral famotidine, a histamine type 2 receptor antagonist already widely used with very few side effects in other indications in children, is effective in reducing endothelial expression of P-selectin in children with sickle cell disease (SCD). The dosage and length of treatment are based on your medical condition and response to treatment. Since 20 mg or 40 mg tablet strength cannot be used for this dosage regimen, use an alternate famotidine formulation. PEDIATRIC PATIENTS 1-16 YR. Peptic ulcer: 0.5 mg/kg/day PO hs or divided in two doses up to 40 mg/day; 0.25 mg/kg q 12 hr IV up to 40 mg/day if unable to take orally or for pathological hypersecretory conditions. Famotidine for oral suspension is indicated in pediatric patients from birth to less than 1 year of age for the treatment of: GERD. A high dose of famotidine, commonly known as Pepcid®, was found to have beneficial effects in adult patients with coronavirus disease 2019 (COVID-19), according to results of an outpatient clinical trial. Table 1: Recommended Dosage and Duration of PEPCID for Oral Suspension . Famotidine was approved by the FDA in 1995, and is available either with or without a prescription. PEDIATRIC DOSING GUIDELINES - ANALGESICS / SEDATIVES DRUG DOSE INTERVAL (hr) Acetaminophen 10 - 15 mg/kg/dose Q4-6 (Max: < 2 years: 60 mg/kg/day; ≥ Albumin2 years: 75 mg/kg/day . at bedtime or divided b.i.d. Children weighing less than 40 kg—Use and dose be determined by your doctor. Benign gastric ulcer The recommended dose of famotidine is one 40 mg tablet daily taken at night. The recommended adult intravenous dose is 20 mg q 12 h. . A possibly efficacious famotidine dose for infants is 0.5 mg/kg (frequency adjusted for age). . To treat erosive esophagitis (heartburn): Adults and children weighing 40 kilograms (kg) or more—20 milligrams (mg) 1 or 2 times per day, at the morning and at bedtime, or 40 mg once a day at bedtime for up to 12 weeks. Intravenous dosage: Children and Adolescents: 0.25 mg/kg/dose IV every 12 hours (Max: 40 mg/day) is recommended by the manufacturer. Famotidine 10mg, calcium carbonate 800mg, magnesium hydroxide 165mg; chew tabs; cool mint- and berry blend-flavors. As 1.0 mg/kg may be more efficacious in some, the dosage may require individualization based on response. In pediatric Famotidine 0.5 mg/kg/dose (Max: 20 mg) (1 - 3mo)DAILY, (≥3mo)BID DAILY-BID Exceptions to legal category For famotidine The recommended adult intravenous dose is 20 mg q 12 h. Although an intravenous famotidine formulation was available, no patients were treated with . 40mg PO qhs x4-6 weeks; Alt dosing: 20mg PO BID or 20mg IV q12 hr; Maintenance duodenal ulcer. . Pharmacology, adverse reactions, warnings and side effects. For pediatric patients weighing less than 40 kg, consider another famotidine formulation (e.g., oral suspension, lower dose . In a study examining the effect of famotidine on gastric pH and duration of acid suppression in pediatric patients, four pediatric patients ages 11 to 15 years of age using the oral formulation at a dose of 0.5 mg/kg, maintained a gastric pH . . Talk with the doctor. Table 1: Recommended Dosage and Duration of PEPCID Tablets in Adult and Pediatric Patients 40 kg and The FDA-approved product labeling recommends the following dosage adjustments in adult and pediatric patients 40 kg and more: Active DU or Active GU: CrCl 30 to 60 mL/minute: 20 mg once daily or 40 mg every other day. Findings from the. A typical dose regime is 0.25 to 0.5 mg per pound or 0.5 to 1.0 mg/kg every 12 to 24 hours. Pediatric Dosage Calculator. Famotidine and Renal Dosing. …disease are discussed elsewhere. Child dose by weight = (mg/day) = Adult Dose in mg/kg or mg/kg/day x Child Weight in kg OR PEDIATRIC DOSING GUIDELINES - ANALGESICS / SEDATIVES DRUG DOSE INTERVAL (hr) Acetaminophen 10 - 15 mg/kg/dose Q4-6 (Max: < 2 years: 60 mg/kg/day; ≥ Albumin2 years: 75 mg/kg/day . famotidine be continued with a dose of one 20 mg tablet daily taken at night. 0.5 mg/kg/dose PO twice daily (Max: 40 mg PO twice daily). . The studies described in PRECAUTIONS, Pediatric Use suggest that the starting dose in pediatric patients 1 to 16 years of age is 0.25 mg/kg intravenously . Dosage Adjustments for Patients with Moderate or Severe Renal Insufficiency. maint. Adults and children weighing 40 kilograms (kg) or more—20 milligrams (mg) 2 times per day, at the morning and at bedtime, or 40 mg once a day at bedtime for up to 8 weeks. PEPCID 20 and 40 mg tablets are not recommended for use in pediatric patients weighing less than 40 kg because these tablet strengths exceed the recommended dose for these patients [see Dosage and Administration (2.1)]. The dosage regimen recommended for elderly patients is the same as for adults. Usual Pediatric Dose for Peptic Ulcer. Use a leading zero if it applies. Use another famotidine formulation for pediatric patients weighing less than 40 kg. Children Dosage . . Includes Famotidine indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Children Dosage: Individualize; adjust . Pediatric: CrCl 10-50: decrease dose 50% or give q24 hr, CrCl<10: give q36-48 hr; Hepatic Dosing. Methods: Infants in Part I were administered a single dose of famotidine 0.5 mg/kg; the dose was intravenous or oral according to the judgement of the attending physician. Prior to treatment and 30 min after treatment, patients rated pruritus and sedation using visual analogue scales, while physicians . Adults and children weighing 40 kilograms (kg) or more—20 milligrams (mg) 2 times per day, at the morning and at bedtime, or 40 mg once a day at bedtime for up to 8 weeks. Adults—20 milligrams (mg) every 6 hours. Reduce dosage to 20 . Pronunciation: To treat too much stomach acid (Zollinger-Ellison syndrome): Adults—20 milligrams (mg) every 6 hours. this is a calculation for ONE dose & you give this ONE dose THREE times a day] a nurse is preparing to administer famotidine 1 mg/kg/day PO divided equally every 12 hr to a child who weighs 41 lbs. For patients with severe renal insufficiency, it may exceed 20 hours, reaching . Dosage varies from cat to cat; underlying health problems must be taken into consideration when deciding the safe dose. Famotidine Injection 10 mg/mL, is a preserved, clear, colorless solution and is supplied as follows: NDC 55390-028-10, 4 mL two dose vial, carton of 10. Dose adjustments Use normal dose every 36-48 hours or use half normal dose if eGFR less than 50 mL/minute/1.73 m 2. Stress ulcers in the intensive care unit . Th adult dosage is recommended for children 12 years of age or older. The primary clinically important pharmacologic activity is inhibition of gastric juice secretion. or diphenhydramine 50 mg i.m. Famotidine liquid for injection has the preservative benzyl alcohol which can cause serious reactions in newborn children. Although an intravenous famotidine formulation was available, no patients were treated with . Age 0-3 months. To treat erosive esophagitis (heartburn): Adults and children weighing 40 kilograms (kg) or more—20 milligrams (mg) 1 or 2 times per day, at the morning and at bedtime, or 40 mg once a day at bedtime for up to 12 weeks. Table 2: Recommended Maximum Dosage of Famotidine Tablets in Adult and Pediatric Patients 40 kg and Greater with Moderate and Severe Renal Impairment a An alternate dosage regimen is 10 mg once daily. In people with normal renal function, famotidine is a . 20mg PO qhs; . Famotidine Oral Suspension Dosage and Administration Recommended Dosage in Adults The recommended dosage and duration of famotidine for oral suspension in adults with normal renal function is shown in Table 1. 3. It is important to note whether the dosage starts from the daily dose or the dose per administration. The administration of famotidine significantly reduced the number of pediatric patients considered at higher risk for aspiration pneumonitis, despite not decreasing gastric . . The Famotidine-Famotidine group received one dose of famotidine at 22:00 the evening before surgery and a second dose 60-90 min before the scheduled time of surgery.

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famotidine dosage pediatric